Summary
This project investigates how the Staphylococcus aureus enzyme SagB processes peptidoglycan to modulate host IL-1β immune responses, influencing infection and inflammatory pathology.
Bacterial cell wall remodeling, innate immunity, and pathogenesis
US · IL
NIH
grant
awarded
#nih-1R01AI194356-01
What they want
The project aims to determine how and where SagB-modified peptidoglycan products are recognized by innate immune cells, investigating how peptidoglycan cross-linking and glycan length drive recognition. It will also investigate the mechanism of SagB-dependent IL-1β maturation and release. Furthermore, the project will establish how SagB promotes infection during local and disseminated infection and ascertain how peptidoglycan synthesis enzymes or cell wall targeting antibiotics interface with SagB to promote infection.
