Connectivity and function of inhibitory neurons in the primate visual cortex

The project will investigate the laminar- and subtype-specific connectivity and function of PV-INs in primate visual cortex. This will be achieved by using rabies-virus monosynaptic circuit tracing combined with optical imaging of cortical functional maps to map local and brain-wide inputs to PV-INs and two of their major subtypes in distinct layers, and to understand their functional connectivity. Optogenetic manipulations of PV-INs and their subtypes in distinct layers will be used to understand their computational functions. Finally, the connectivity of PV-INs, derived from anatomical studies and mouse data, will be incorporated into a neural network model of V1 to reproduce optogenetics manipulations and generate novel predictions.