← Back to contracts

NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

US · US National Institutes of Health (NHLBI) grant open #PAR-25-447
Response due May 08, 2028 · 00:00 UTC

Summary

The National Heart, Lung, and Blood Institute (NHLBI) is soliciting X01 resource access applications under the Trans-Omics for Precision Medicine (TOPMed) program. The opportunity focuses on generating and analyzing omics data (e.g., genomics, transcriptomics, proteomics, metabolomics) linked to phenotypes of heart, lung, and blood disorders. Clinical trials are explicitly not allowed under this funding mechanism. The program aims to advance precision medicine research by integrating multi-omics data with existing cohort or study datasets.

What they want

Applicants must propose research leveraging NHLBI's TOPMed program infrastructure to study omics-based phenotypes relevant to heart, lung, and blood disorders. The X01 mechanism provides access to TOPMed resources (e.g., whole genome sequencing data, cloud computing environments). Clinical trials are not permitted. Projects must align with NHLBI priorities for precision medicine and multi-omics integration. Applicants gain access to centrally generated omics data for approved research projects rather than receiving direct funding for data generation.
Technical requirements
  • Research must utilize NHLBI TOPMed program infrastructure and omics data resources
  • Clinical trials are not allowed under this funding mechanism (X01)
  • Projects must focus on omics phenotypes related to heart, lung, and/or blood disorders
  • Access to centrally generated omics data (e.g., whole genome sequencing) is provided rather than direct funding for data generation

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Extremely long open window (nearly 3 years, September 2025 – May 2028) may indicate rolling review cycles but warrants monitoring for any mid-cycle scope narrowing
  • X01 resource access mechanism restricts eligibility to investigators with pre-existing cohort data compatible with TOPMed infrastructure, which may inherently limit competition to established TOPMed-affiliated groups

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

NHLBI TOPMed: Omics Phenotypes of Heart, L…
Due May 08
Onboard ↗