Summary
Research project focused on the mechanism and inhibition of HIV reverse transcriptase, specifically developing new non-nucleoside reverse transcriptase inhibitors (NNRTIs) to combat drug resistance and explore novel mechanisms of action.
Mechanism and Inhibition of HIV Reverse Transcriptase
US · IL
National Institutes of Health (NIH)
grant
open
#nih-5R37AI155072-33
What they want
The project involves building on the discovery of novel lead compounds using computational and structure-guided design to optimize new classes of NNRTIs. These compounds are being developed as preclinical candidates for combination therapy and PrEP, with a focus on improved safety, pharmacological properties, and efficacy against drug-resistant HIV strains. The research also investigates a new class of Gag-Pol dimerizer NNRTIs that induce premature HIV protease activation and CARD8-mediated inflammasome cell-killing to attack HIV reservoirs.
Risks & flags
- This document appears to be a summary of an existing or proposed research project (e.g., grant abstract) rather than a competitive procurement opportunity (RFP, IFB, RFQ). It describes the work of a Principal Investigator and collaborators, not work being solicited from external vendors.
