Summary
PROJECT SUMMARY The entorhinal cortex (EC) is a critical mediator of cortico-hippocampal communication and thus essential for memory. Numerous studies identify the EC as the first brain region to display age-related changes such as accumulation of tau protein as related to Alzheimer’s disease (AD). Structural and functional changes to the EC have been found to precede and even predict future cognitive impairment. The EC is comprised of two subdivisions that are anatomically and functionally distinct, the lateral EC (LEC) and medial EC (MEC). Human studies have found that of these, the LEC is t
