Summary
The Immunology Program conducts basic immunology studies and translates findings into effective cancer immunotherapy, focusing on immune regulation, checkpoint blockade, cancer vaccines, and T-cell therapies.
04 Immunology
US · IL
National Cancer Institute (NCI)
grant
awarded
#nih-5P30CA016672-49
What they want
The program focuses on four themes: 1) immune regulation, aiming to understand fundamental mechanisms involved in regulating innate and adaptive immune responses; 2) immune checkpoint blockade, aiming to elucidate fundamental cellular and molecular mechanisms of immune checkpoints and their impact on the tumor microenvironment using preclinical models and clinical trials; 3) cancer vaccines, aiming to identify novel targets for cancer vaccine development; and 4) T-cell therapies, aiming to improve the success rate of T-cell-based therapies using a combinatorial approach. The Immunotherapy Platform fosters iterative cycles of translation between basic and clinical work by providing immune monitoring of patient samples and driving new preclinical and clinical studies.
Deliverables
- 464 published papers
- Demonstration that anti-CTLA-4 and anti-PD-1 therapies act on distinct T-cell populations
- Discovery of a positive correlation between gut microbiome diversity and response to immune checkpoint blockade therapy
