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Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)

US National Institutes of Health (NIH) grant open #PAR-25-286
Response due Jan 07, 2028 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting R21 exploratory/developmental research grant applications focused on the development of neuromodulation and neurostimulation devices for mental health applications. Clinical trials are explicitly not allowed under this funding opportunity. The opportunity is open for an extended multi-year window, reflecting a standing program announcement rather than a one-time solicitation. Applicants are expected to propose early-stage device development research relevant to psychiatric or mental health conditions.

What they want

Technical requirements
  • No clinical trials allowed
  • R21 exploratory/developmental research mechanism
  • Research must be focused on neuromodulation or neurostimulation device development
  • Applications must target mental health applications

How they evaluate

Submission: Grants.gov federal grants portal (PAR-25-286)

Risks & flags

  • Extended close date through 2028 suggests rolling/standing program announcement — not a competitive single-award RFP; standard NIH programmatic notice
  • Restriction on clinical trials (Not Allowed) may limit applicant pool to early-stage device researchers only

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Neuromodulation/Neurostimulation Device De…
Due Jan 07
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