Non-Invasive Venous waveform Analysis (NIVA) for Monitoring Volume Status in Heart Failure Patients

Summary

This research project focuses on refining and optimizing the Non-Invasive Venous waveform Analysis for Heart Failure (NIVAHF) device to accurately monitor volume status in heart failure patients, specifically addressing challenges posed by tricuspid regurgitation, orthotopic heart transplantation, and left ventricular assist devices.

What they want

The project involves the refinement and advanced optimization of the NIVAHF device, building upon prior foundational achievements. It aims to investigate and overcome three major limitations in venous waveform analysis for heart failure patients: tricuspid regurgitation (TR), orthotopic heart transplantation (OHT), and left ventricular assist device (LVAD) support. This includes characterizing the relationship between TR severity and the NIVA Score, recalibrating device precision for TR patients, developing an OHT-specific NIVAHF algorithm for early graft anomaly detection, and crafting an AI-driven neural network algorithm tailored for HeartMate 3 (HM3) LVAD patients.

Deliverables

Recalibrated NIVAHF device precision for patients with varying TR stages
OHT specific NIVAHF algorithm
AI-driven neural network algorithm tailored for HM3 LVAD patients
A dependable, non-invasive PCWP monitoring device with NIVAHF for vulnerable heart failure patients

Technical requirements

AI neural network algorithm
NIVA Score generation
Pulmonary capillary wedge pressure (PCWP) equivalent value calculation
Compatibility/tailoring for HeartMate 3 (HM3) LVAD patients

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541714

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.