Role of HMGB1 in an experimental model of Bacterial ligand induced Vasculitis

US · IL NIH grant open #nih-1R21AI193709-01

Summary

This research project aims to investigate the role and cellular source of High mobility group box 1 (HMGB1) in a bacterial ligand-induced murine model of Kawasaki Disease (KD) vasculitis to better understand its pathogenesis and identify potential novel therapeutic targets.

What they want

The study will determine the role of HMGB1 in Lactobacillus casei cell wall extract (LCWE)-induced KD vasculitis using anti-HMGB1 monoclonal antibodies (mAb) and a peptide/protein inhibitor of HMGB1. Additionally, it will explore the role of HMGB1 in platelets and neutrophils in LCWE-induced KD vasculitis by utilizing cell-specific HMGB1 knockout mice. The ultimate goal is to reveal HMGB1's contribution to regulating the innate immune response during LCWE-induced KD vasculitis and identify potential novel biomarkers and therapeutic targets for KD.

Deliverables

Potential novel biomarkers for KD
Potential novel therapeutic targets for KD

Technical requirements

Lactobacillus casei cell wall extract (LCWE)-induced murine model of KD vasculitis
Anti-HMGB1 mAb
Peptide/protein inhibitor of HMGB1
Cell-specific HMGB1 knockout mice

Market context

inferred from NAICS

R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)

NAICS 541715

US market size: $95B
Typical award: $100K – $50M+

Typical buyers

DoDNSFNIHNASADOE

Commonly required

DCAA-compliant accountingITARCMMC L2

Role of HMGB1 in an experimental model of …

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