Summary
The proposed research will demonstrate the therapeutic efficacy of one or more gamma aminobutyric acid type A receptor (GABAAR) modulators in reducing acute lung injury (ALI) caused by inhaled chlorine. The research is significant because it supports the mission of the Chemical Countermeasures Research Program (CCRP) to address the nation's medical response capabilities during chemical emergencies. Deliberate or accidental release of chlorine represents a serious threat for civilians, chemical industry workers and people involved in transport and distribution of chemicals. Medical countermeasu
