← Back to contracts

Precision characterization of antimicrobial resistance gene dynamics in bloodstream infection risk after hematopoietic stem cell transplantation

US · NC NIH grant awarded #nih-5K23AI163365-05

Summary

Research to precisely track the development and dissemination of antibiotic resistant organisms in immunocompromised patients, specifically focusing on antimicrobial resistance (AMR) gene dynamics in gut flora of hematopoietic stem cell transplantation (HCT) recipients to prevent bloodstream infections.

What they want

The research involves applying next-generation sequencing technologies to characterize antibiotic resistance genes in gut flora from stool samples of 70 HCT recipients at two institutions. Specific aims include determining the timing of AMR gene acquisition relative to transplant, the extent of AMR gene transfer and dissemination between gut bacteria, and the relationship between AMR gene burden and bloodstream infection risk after HCT.
Technical requirements
  • next-generation sequencing technologies
Precision characterization of antimicrobia…
Onboard ↗