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Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-27-012
Response due Nov 02, 2028 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting applications for a Clinical Coordinating Center (CCC) to support multi-site investigator-initiated clinical trials. The opportunity is structured as a collaborative UG3/UH3 phased award mechanism, where UG3 represents a planning/milestone-driven phase and UH3 represents the implementation phase. The CCC is expected to provide centralized coordination functions across multiple trial sites. The opportunity is open from March 2026 through November 2028, suggesting a rolling or multiple-cycle submission process.

What they want

Applicants must propose and operate a Clinical Coordinating Center (CCC) to support multi-site investigator-initiated clinical trials under a collaborative UG3/UH3 award mechanism. The UG3 phase typically involves trial planning, protocol development, and milestone achievement prior to progression to the UH3 implementation/execution phase. The CCC is responsible for coordinating clinical activities across multiple participating sites for one or more clinical trials. A clinical trial is required as part of the application.
Technical requirements
  • Must propose a clinical trial as part of the application (Clinical Trial Required)
  • Must use the Collaborative UG3/UH3 award mechanism
  • UG3 phase requires milestone-driven planning prior to UH3 progression
  • Must support multi-site trial coordination

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Extremely long open window (March 2026 – November 2028) suggests a Program Announcement with Review (PAR) with multiple receipt dates rather than a single competition — not inherently a red flag but warrants monitoring of specific receipt dates
  • Limited scope detail in the synopsis may obscure specific eligibility or organizational requirements hidden in the full funding opportunity announcement

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Clinical Coordinating Center for Multi-Sit…
Due Nov 02
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