NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)

US · DC National Institutes of Health (NIH) grant open #PA-25-303

Response due May 24, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting Research Project Grant (R01) applications for basic experimental studies involving human subjects. This is a parent/omnibus funding opportunity announcement (FOA) covering a broad range of basic science research disciplines. Applicants must propose studies that qualify as Basic Experimental Studies with Humans (BESH), meaning the research involves human participants and is considered basic science rather than clinical research. The opportunity is open from December 2024 through May 2026, allowing multiple submission cycles.

What they want

Applicants must submit R01 research project grant proposals for basic experimental studies that involve human participants. Proposed research must meet NIH's definition of Basic Experimental Studies with Humans (BESH) — i.e., studies that prospectively assign human participants to experimental conditions but are primarily aimed at understanding fundamental biological/behavioral mechanisms rather than a clinical outcome. Submissions must follow NIH grant application requirements and adhere to all human subjects research protections.

Technical requirements

Research must qualify as Basic Experimental Studies with Humans (BESH) under NIH definition
Prospective assignment of human participants to experimental conditions required
Research must be classified as basic science (not clinical research)
Must comply with NIH human subjects research requirements and protections

How they evaluate

Submission: Grants.gov electronic submission portal (NIH eRA Commons)

Eligibility & certifications

SAM registration (Grants.gov eligibility)IRB approval / human subjects research protections (Common Rule compliance)NIH eRA Commons registration

Risks & flags

Omnibus/parent FOA with broad scope — no single-bidder wiring detected
Multiple submission cycles across 18-month window reduce urgency pressure

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541714

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

NIH Research Project Grant (Parent R01 Bas…

Due May 24

Onboard ↗