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Single Source: HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Data Translation Center (U54 Clinical Trial Optional)

US National Institutes of Health (NIH) grant open #RFA-HL-27-009
Response due Jul 09, 2026 · 00:00 UTC

Summary

This is a single-source federal grant/cooperative agreement opportunity issued by the National Institutes of Health (NIH/NHLBI) under RFA-HL-27-009. It funds a Data Translation Center (U54 mechanism) supporting the HeartShare 2.0 initiative, which aims to refine heart failure subtypes and identify treatment targets for personalized clinical trials. As a single-source notice, NIH intends to award to one specific recipient without full competition. The U54 mechanism is a cooperative agreement allowing substantial NIH programmatic involvement alongside the awardee.

What they want

The Data Translation Center (DTC) will support the HeartShare 2.0 program by: (1) integrating and translating multi-source heart failure data to refine disease subtypes; (2) identifying treatment targets suitable for personalized/precision clinical trials; (3) collaborating with NIH program staff under a U54 cooperative agreement structure. Clinical trials are optional under this award mechanism. The award is single-source, meaning NIH has pre-identified the intended recipient.
Deliverables
  • Refined heart failure subtype classifications
  • Identified treatment targets for personalized clinical trials
  • Data integration and translation outputs supporting HeartShare 2.0 program goals
  • Collaborative activities with NIH program staff per U54 cooperative agreement terms
Technical requirements
  • U54 Cooperative Agreement mechanism compliance
  • Data translation and integration capabilities for heart failure multi-source datasets
  • Support for optional clinical trial activities
  • Coordination with NIH programmatic staff as required by cooperative agreement

How they evaluate

Submission: Grants.gov federal grants portal submission

Risks & flags

  • Explicitly labeled 'Single Source' — NIH has pre-identified the intended awardee, effectively eliminating open competition
  • No dollar value disclosed, limiting competitive intelligence for any potential challenger
  • U54 cooperative agreement mechanism with substantial NIH involvement may be tailored to a specific institution's existing infrastructure or relationships
  • Short response window of approximately 7 weeks (May 19 – July 09, 2026) is consistent with single-source intent rather than broad competition
  • RFA number (RFA-HL-27-009) suggests this is a recompete or continuation of an existing HeartShare program, likely favoring the incumbent data center

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Single Source: HeartShare 2.0: Refining He…
Due Jul 09
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