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The urothelial glycosaminoglycan layer: composition and contribution to pathogen fitness during catheter-associated urinary tract infection

US National Institute of Diabetes and Digestive and Kidney Diseases grant open #nih-5R01DK136875-03

Summary

Project Summary/Abstract Urinary tract infection (UTI) is one of the most common infections worldwide and a leading cause of morbidity and healthcare expenditures across all ages. Older adults and individuals with catheters have a particularly high risk of UTI sequelae, including kidney infection, permanent renal damage, and urosepsis. The average mortality rate for urosepsis is 20-40%, but ranges as high as 66% for patients with catheter- associated UTI (CAUTI). Catheterization also promotes polymicrobial colonization and infection by a wide range of understudied microbes, including multidrug

The urothelial glycosaminoglycan layer: co…
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