Summary
Project Summary Background and Innovation. Chronic infections and the inflammation associated with long-term immune activation contribute to carcinogenesis in several tissues, especially gastrointestinal infections. Specifically, Helicobacter pylori infection has been formally recognized as a Type I carcinogen for over many years. More recently, associations between bacterial infections and colorectal cancer have been made (i.e. enterotoxigenic Bacteroides fragilis, pks+ E. coli, F. nucleatum). We use H. pylori as a highly relevant, rigorous and tractable model to investigate an understudied a
