The role of alpha-adrenergic vasoconstriction on blood flow to exercising skeletal muscle in patients with heart failure with preserved ejection fraction

Summary

This research project aims to determine how alpha-adrenergic vasoconstriction limits leg blood flow and oxygen consumption in exercising skeletal muscle, and how well exercising muscle can counteract this vasoconstriction, in Veterans with Heart Failure with preserved ejection fraction (HFpEF).

What they want

The overall research objective is to determine the extent to which alpha-adrenergic vasoconstriction may limit leg blood flow and VO2 (Aim 1) and the ability of exercising muscle to counteract SNS-mediated vasoconstriction (Aim 2) as potential mechanisms underlying low VO2peak in Veterans with HFpEF. The project also includes scientific and professional training in clinical science, vascular, and exercise physiology to support the career goal of becoming an independent VA scientist.

Deliverables

Successful identification of vascular mechanisms underpinning exercise intolerance in HFpEF
Training necessary for a subsequent VA CDA-2 Award application

Technical requirements

Direct measurements of arterial and venous O2 across the skeletal muscle
Investigation of alpha-adrenergic vasoconstriction
Evaluation of functional sympatholysis specifically regarding alpha1-adrenergic vasoconstriction

Key personnel

Independent VA scientist with expertise in neurovascular and exercise physiology