← Back to contracts

Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study

US · IL NIH grant open #nih-5R01HL163081-04

Summary

A genotype-guided human physiological study will investigate the role of atrial natriuretic peptide (ANP) and microRNA-425 (miR-425) in cardiometabolic health, specifically examining responses to glucose and exercise challenges.

What they want

The project proposes to conduct a genotype-guided study involving detailed metabolic profiling among individuals with high and low ANP genotypes. Aim 1 will enroll 200 healthy adults (50 with high ANP genotype and 150 with low ANP genotype) to assess the difference in response of MRproANP, glucose, and insulin levels to a glucose challenge by genotype groups. Aim 2 will assess the difference in energy expenditure (EE) during rest and exercise, and the response of ANP, glucose, insulin, and markers of fat breakdown to a standardized exercise challenge between the two genotype groups. Aim 3 will assess changes in miR-425 expression after glucose and exercise challenges among those with low ANP genotype, and its association with changes in MRproANP, glucose, and insulin levels. The study aims to provide insights into the ANP system's role in cardiometabolic health and generate evidence for RNA-based treatment approaches.
Deliverables
  • Detailed metabolic profiling of participants based on ANP genotype
  • Insights into the role of the ANP system in cardiometabolic health
  • Evidence supporting the biological basis for developing RNA-based novel treatment approaches
Technical requirements
  • Genotype assessment for rs5068 variant
  • Enrollment of 200 healthy adults (50 high ANP genotype, 150 low ANP genotype)
  • Oral glucose challenge administration
  • Standardized exercise challenge administration
  • Measurement of MRproANP levels
  • Measurement of glucose levels
  • Measurement of insulin levels
  • Measurement of microRNA-425 (miR-425) expression
  • Assessment of energy expenditure (EE) during rest and exercise
  • Measurement of markers of fat breakdown

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Atrial Natriuretic Peptide and Regulation …
Onboard ↗