← Back to contracts

Microbial Metabolites Inhibiting Salmonella Carriage and Disease

US · IL NIH grant awarded #nih-5R01AI172433-04

Summary

This research project aims to identify microbial metabolites (Diffusible Signal Factors or DSFs) from the human gut microbiome that inhibit Salmonella virulence and colonization, with the ultimate goal of developing novel therapeutics for human salmonellosis.

What they want

The project proposes three main aims: 1) Use complementary approaches to identify bacteria of the human gut microbiome that produce inhibitory DSFs and characterize their products; 2) Identify the constellation of functions regulated in Salmonella by DSFs and identify mechanisms of this control; and 3) Using established murine models of Salmonella infection, characterize the biological function and translational relevance of cis-2 hexadecenoic acid (c2-HDA) to understand its mechanism of action and to support the eventual development of novel therapeutics, such as live biotherapeutic products, for the control of human salmonellosis.
Deliverables
  • Identification of bacteria in the human gut microbiome that produce inhibitory DSFs
  • Characterization of inhibitory DSF products
  • Identification of functions regulated in Salmonella by DSFs
  • Identification of mechanisms of DSF control in Salmonella
  • Characterization of the biological function of c2-HDA in murine models of Salmonella infection
  • Characterization of the translational relevance of c2-HDA for human salmonellosis
  • Understanding of c2-HDA's mechanism of action
  • Support for the eventual development of novel therapeutics (e.g., live biotherapeutic products) for human salmonellosis
Technical requirements
  • Use of complementary approaches to identify bacteria and characterize products
  • Use of established murine models of Salmonella infection

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Microbial Metabolites Inhibiting Salmonell…
Onboard ↗