GENERATION, CHARACTERIZATION, AND VALIDATION OF MARMOSET MODELS OF ALZHEIMER'S DISEASE - PROJECT SUMMARY OVERALL ALZHEIMER’S DISEASE (AD) IS A DEVASTATING NEURODEGENERATIVE DISORDER AFFECTING NEARLY 6 MILLION AMERICANS AND IS EXPECTED TO INCREASE OVER THE NEXT SEVERAL YEARS. OUR LIMITED UNDERSTANDING OF THE MECHANISMS THAT TRIGGER THE EMERGENCE OF AD HAS CONTRIBUTED TO THE LACK OF INTERVENTIONS THAT STOP, PREVENT, OR FULLY TREAT THIS DISEASE. WE PROPOSE TO ESTABLISH THE MARMOSET AS THE FIRST PRIMATE-SPECIFIC MODEL TO REVEAL THE EARLIEST CELLULAR AND MOLECULAR EVENTS OF AD PROCESSES AND ALLOW CHARTING AD PROGRESSION FROM ITS INCEPTION. TO DO SO, WE WILL DRAW FROM A SELF-SUFFICIENT AND LARGE COLONY OF RESEARCH MARMOSETS WITH DEDICATED VETERINARY AND HUSBANDRY TEAMS, STATE-OF-THE-ART IN VIVO NEUROIMAGING AND MOLECULAR ASSAYS, AND A MULTIDISCIPLINARY TEAM OF EXPERTS IN AGING BIOLOGY, AD GENETICS AND GENOMICS, ANIMAL MODEL DEVELOPMENT AND CHARACTERIZATION, BEHAVIORAL AND COGNITIVE PHENOTYP

Summary

GENERATION, CHARACTERIZATION, AND VALIDATION OF MARMOSET MODELS OF ALZHEIMER'S DISEASE - PROJECT SUMMARY OVERALL ALZHEIMER’S DISEASE (AD) IS A DEVASTATING NEURODEGENERATIVE DISORDER AFFECTING NEARLY 6 MILLION AMERICANS AND IS EXPECTED TO INCREASE OVER THE NEXT SEVERAL YEARS. OUR LIMITED UNDERSTANDING OF THE MECHANISMS THAT TRIGGER THE EMERGENCE OF AD HAS CONTRIBUTED TO THE LACK OF INTERVENTIONS THAT STOP, PREVENT, OR FULLY TREAT THIS DISEASE. WE PROPOSE TO ESTABLISH THE MARMOSET AS THE FIRST PRIMATE-SPECIFIC MODEL TO REVEAL THE EARLIEST CELLULAR AND MOLECULAR EVENTS OF AD PROCESSES AND ALLOW CHARTING AD PROGRESSION FROM ITS INCEPTION. TO DO SO, WE WILL DRAW FROM A SELF-SUFFICIENT AND LARGE COLONY OF RESEARCH MARMOSETS WITH DEDICATED VETERINARY AND HUSBANDRY TEAMS, STATE-OF-THE-ART IN VIVO NEUROIMAGING AND MOLECULAR ASSAYS, AND A MULTIDISCIPLINARY TEAM OF EXPERTS IN AGING BIOLOGY, AD GENETICS AND GENOMICS, ANIMAL MODEL DEVELOPMENT AND CHARACTERIZATION, BEHAVIORAL AND COGNITIVE PHENOTYP