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Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)

US · MD National Institutes of Health (NIH) — National Institute of Mental Health (NIMH) grant open #RFA-MH-27-135
Response due Oct 11, 2026 · 00:00 UTC

Summary

This NIH funding opportunity (RFA-MH-27-135) solicits R01 research grant applications focused on addressing methodological challenges associated with clinical trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs). The opportunity is posted under the National Institute of Mental Health (NIMH) and explicitly requires a clinical trial component. Applicants are expected to propose novel or improved research methodologies to overcome specific scientific and operational hurdles encountered in conducting rigorous clinical trials for this drug class.

What they want

Applicants must design and propose R01-level research that identifies and addresses methodological challenges inherent in conducting clinical trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs). The clinical trial component is required, not optional. Research should contribute to improved scientific rigor and methodological standards for this class of interventional studies in the mental health domain.
Technical requirements
  • Clinical trial must be included as a required component of the research design
  • Research must address methodological challenges specific to Rapid-Acting Psychotropic Interventional Drugs (RAPIDs)
  • Must conform to NIH R01 grant application requirements and format

Risks & flags

  • Opportunity is a federal grant (not a procurement contract) — competitive R01 grant mechanism; applicants must follow NIH R01 application requirements which carry significant regulatory and compliance burden
  • Clinical trial requirement mandates specific infrastructure and oversight (IRB, data safety monitoring, etc.) that may disadvantage smaller institutions

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Addressing Methodological Challenges with …
Due Oct 11
Onboard ↗