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BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)

US National Institutes of Health (NIH) grant open #RFA-DA-27-004
Response due Nov 08, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH), under the BRAIN Initiative, is soliciting R01 research grant applications focused on the development of theories, models, and analytical methods for complex neuroscience data. Clinical trials are explicitly excluded from this funding opportunity. The opportunity is posted on Grants.gov under RFA-DA-27-004 and is open for submissions from September 2025 through November 2027. This is a federal grant (not a procurement contract), targeting researchers advancing computational and analytical frameworks for brain data.

What they want

Applicants must propose research developing novel theories, mathematical/computational models, and methods for the analysis of complex data generated from brain research conducted under the NIH BRAIN Initiative. Clinical trials are not allowed under this funding opportunity announcement (FOA). The mechanism is R01 (Research Project Grant). The solicitation number is RFA-DA-27-004, indicating primary management by the National Institute on Drug Abuse (NIDA) on behalf of NIH.
Technical requirements
  • Proposals must focus on theories, models, or analytical methods for complex brain data
  • Clinical trials are not allowed
  • Must align with NIH BRAIN Initiative objectives
  • R01 grant mechanism applies

How they evaluate

Submission: Grants.gov electronic submission portal

Risks & flags

  • Clinical trial exclusion is a scope restriction that may limit eligible applicants
  • Long open window (over 2 years) is atypical for standard RFPs but normal for NIH standing FOAs — not necessarily a red flag in the grants context

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
BRAIN Initiative: Theories, Models and Met…
Due Nov 08
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