Summary
Summary: Mast cells (MCs) are best known for their roles in IgE-mediated allergic disorders. However, the recent identification of Mas-related G protein coupled receptor-X2 (MRGPRX2) in human cutaneous MCs (MrgprB2; mouse counterpart) as the receptor for antimicrobial peptides, neuropeptides and chemokines has revolutionized the way in which MCs are viewed. Furthermore, the development of MrgprB2-/- mice has been instrumental in delineating the roles of this receptor in non-IgE-mediated disorders. However, it now appears that expression of MrgprB2 is not restricted to cutaneous MCs and that i
