Summary
Development of fast, high-resolution, whole-brain quantitative metabolic multinuclear MRI for image-guided therapy of glioma patients to improve precision oncology treatments.
Development of multinuclear MRI for image guided therapy of glioma patients
US · IL
NIH
grant
awarded
#nih-5R01CA211080-08
What they want
The project aims to develop non-invasive metabolic cancer imaging tools for personalized precision oncology. This involves three specific aims: 1) developing 1H-MRSI for intra-operative image-guided surgical removal of gliomas, 2) developing 31P-MRSI at ultra-high field to guide pharmacologic interventions in glioma, and 3) clinical translation of multinuclear MRI for the treatment of glioma patients.
Deliverables
- 1H-MRSI for intra-operative image guided surgical removal of gliomas
- 31P-MRSI at ultra-high field to guide pharmacologic interventions in glioma
- Clinical translation of multinuclear MRI for treatment of glioma patients
- Validated precision oncology imaging tool
Technical requirements
- Multinuclear MR imaging
- 1H-MRSI (Proton Magnetic Resonance Spectroscopic Imaging)
- 31P-MRSI (Phosphorus Magnetic Resonance Spectroscopic Imaging)
- Ultra-high field MRSI
- Whole-brain 2HG imaging at high resolution
- Deep learning compressed sensing
- Novel receive-shim array hardware for 31P-MRSI
- Automated high-throughput processing by deep learning
