Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)

US National Institutes of Health (NIH) grant open #RFA-ES-27-004

Response due Sep 25, 2028 · 00:00 UTC

Summary

This is a limited competition federal grant opportunity from the National Institutes of Health (NIH) under the Superfund Hazardous Substance Research and Training Program (P42 mechanism). It supports research and training related to hazardous substances found at Superfund sites. Clinical trials are optional under this funding opportunity. The opportunity has a long open window, running from May 2026 through September 2028, suggesting multiple application cycles or submission dates.

What they want

Technical requirements

Clinical trial capability optional but must be addressed in application
Must conform to NIH P42 center grant mechanism requirements
Research must relate to hazardous substances at Superfund sites

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

Limited competition designation restricts the eligible applicant pool, potentially favoring existing Superfund Research Program (SRP) center grantees
Extremely long open window (over 2 years) may indicate a renewal/recompete mechanism designed for incumbents
P42 center grant mechanism is historically awarded to established research institutions with prior SRP funding

Market context

inferred from NAICS

R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)

NAICS 541715

US market size: $95B
Typical award: $100K – $50M+

Typical buyers

DoDNSFNIHNASADOE

Commonly required

DCAA-compliant accountingITARCMMC L2

Limited Competition: Superfund Hazardous S…

Due Sep 25

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