Summary
Research project to define the biological role and therapeutic implications of long noncoding RNAs (lncRNAs) in multiple myeloma (MM) and develop potential therapeutic targets.
Project 3: Defining the biologic role and therapeutic implications of lncRNA in multiple myeloma
US · IL
National Institutes of Health (NIH)
grant
awarded
#nih-5P01CA155258-13
What they want
Utilize integrated genomic and epigenomic analysis, in vitro and in vivo models of MM cells in the bone marrow milieu to identify molecular targets and pathways. Specifically, validate the role of novel lncRNAs of biologic/prognostic significance and develop single and combination therapies directed against these clinically and biologically relevant novel lncRNAs. Leverage genomic and transcriptomic data to define the functional landscape of lncRNAs in MM and their impact on disease pathobiology.
Deliverables
- Validation of novel lncRNAs in multiple myeloma
- Development of single and combination therapies targeting lncRNAs
Technical requirements
- Integrated genomic and epigenomic analysis
- In vitro and in vivo models of MM cell in the bone marrow milieu
- Robust human MM model systems
- Genomic and transcriptomic data
