Summary
This project aims to investigate how cholinergic signaling in the basal forebrain influences feeding behavior and body weight control, specifically testing the role of downstream basolateral amygdalar neurons and their projections.
Genetically Dissecting Cholinergic Signaling in Body Weight Control
US · IL
NIH
grant
open
#nih-2R01DK109934-10
What they want
The project will test the hypothesis that downstream basolateral amygdalar (BLA) neurons and their projections to the nucleus of accumbens (NAc) and ventromedial hypothalamus (VMH) mediate forebrain cholinergic action on body weight regulation. This will involve using conditional genetic targeting, optogenetic manipulations, electrophysiology, and behavioral analysis in animal models to determine the role of direct downstream BLA neurons projecting to the NAc or VMH in mediating obesity induced by loss of forebrain cholinergic action.
Deliverables
- Elucidation of roles of specific cholinergic basal forebrain to BLA circuits that differentially regulate the NAc and VMH in feeding and body weight control
- Insight into the central mechanisms underlying appetite and body weight regulation
Technical requirements
- Conditional genetic targeting
- Optogenetic manipulations
- Electrophysiology
- Behavioral analysis
- Use of animal models
Market context
inferred from NAICSProfessional, Scientific & Technical Services
NAICS 541714
- US market size
- $2.0T
- Typical award
- $25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP
Sector-level estimate — full code lookup not yet in catalog.
