Summary
This research project aims to replicate and extend findings on aberrant synaptic plasticity in the medial prefrontal cortex of individuals with Cocaine Use Disorder (CUD) using 11C-UCB-J PET imaging.
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C UCB J PET Study
US · IL
NIH
grant
awarded
#nih-5R01DA052454-05
What they want
The project proposes two experimental aims: Aim 1 involves a larger cohort of 40 CUD and 40 matched healthy control (HC) subjects using a single-scan, between-group design. Aim 2 involves the same 40 CUD subjects using a longitudinal, two-scan (baseline/pre-abstinence vs. 3 weeks of in-hospital abstinence) within-subject design. The study will investigate synaptic density (SV2A availability) and its correlation with cocaine use frequency and abstinence duration.
Technical requirements
- Use of 11C-UCB-J radiotracer for imaging synaptic density
- Positron Emission Tomography (PET) imaging
- Cohort of 40 CUD subjects and 40 matched HC subjects
- Longitudinal study design with two scans (baseline/pre-abstinence vs. 3 weeks in-hospital abstinence) for CUD subjects
