HUMAN PANCREAS ANALYSIS PROGRAM FOR TYPE 1 DIABETES - HPAP-T1D - THE HUMAN PANCREAS ANALYSIS PROGRAM FOR TYPE 1 DIABETES (HPAP-T1D) ABSTRACT IN 2016, THE NIH NIDDK SELECTED A MULTI-DISCIPLINARY TEAM OF INVESTIGATORS FROM THREE INSTITUTIONS (UPENN, VANDERBILT, UNIVERSITY OF FLORIDA) TO ESTABLISH THE PILOT PHASE OF THE HUMAN PANCREAS ANALYSIS PROGRAM (HPAP). OVER THE PAST THREE YEARS, TYPE 1 DIABETES (T1D)-RELEVANT TISSUES FROM MORE THAN 50 ORGAN DONORS WERE PROFILED AT THE ANATOMIC, PHYSIOLOGIC, METABOLIC, IMMUNOLOGIC, GENOMIC AND EPIGENOMIC LEVELS. THE RESULTING DATA WERE COMPILED AND ORGANIZED INTO THE PUBLICLY ACCESSIBLE PANC-DB DATABASE AND WEBSITE. HERE, WE PROPOSE NOT ONLY TO CONTINUE, BUT TO EXPAND OUR EFFORTS TO APPLY AND DEVELOP STATE-OF-THE-ART TECHNOLOGIES DESIGNED TO PHENOTYPE AND MOLECULARLY PROFILE HUMAN TISSUES RELEVANT TO THE ETIOLOGY OF T1D THROUGH A SERIES OF INNOVATIVE EFFORTS BY SIX CORES. CORE A (PANCREAS PROCUREMENT AND ISLET ISOLATION) WILL PROCURE/PROCESS PANCREA

Summary

HUMAN PANCREAS ANALYSIS PROGRAM FOR TYPE 1 DIABETES - HPAP-T1D - THE HUMAN PANCREAS ANALYSIS PROGRAM FOR TYPE 1 DIABETES (HPAP-T1D) ABSTRACT IN 2016, THE NIH NIDDK SELECTED A MULTI-DISCIPLINARY TEAM OF INVESTIGATORS FROM THREE INSTITUTIONS (UPENN, VANDERBILT, UNIVERSITY OF FLORIDA) TO ESTABLISH THE PILOT PHASE OF THE HUMAN PANCREAS ANALYSIS PROGRAM (HPAP). OVER THE PAST THREE YEARS, TYPE 1 DIABETES (T1D)-RELEVANT TISSUES FROM MORE THAN 50 ORGAN DONORS WERE PROFILED AT THE ANATOMIC, PHYSIOLOGIC, METABOLIC, IMMUNOLOGIC, GENOMIC AND EPIGENOMIC LEVELS. THE RESULTING DATA WERE COMPILED AND ORGANIZED INTO THE PUBLICLY ACCESSIBLE PANC-DB DATABASE AND WEBSITE. HERE, WE PROPOSE NOT ONLY TO CONTINUE, BUT TO EXPAND OUR EFFORTS TO APPLY AND DEVELOP STATE-OF-THE-ART TECHNOLOGIES DESIGNED TO PHENOTYPE AND MOLECULARLY PROFILE HUMAN TISSUES RELEVANT TO THE ETIOLOGY OF T1D THROUGH A SERIES OF INNOVATIVE EFFORTS BY SIX CORES. CORE A (PANCREAS PROCUREMENT AND ISLET ISOLATION) WILL PROCURE/PROCESS PANCREA