Summary
This project aims to accelerate bladder tissue formation and enable wireless, real-time monitoring of bladder function using a SMART scaffold for bladder augmentation.
Developing a SMART scaffold for bladder augmentation
US · IL
NIH
grant
awarded
#nih-5R01EB026572-06
What they want
The project will investigate electrically conductive and non-conductive microgrooved poly(1,8 octamethylene citrate-co-octanol) (POCO) scaffolds for accelerated bladder tissue regeneration. It will also explore wireless bioelectronic strategies to monitor real-time bladder dynamics, building on prior demonstrations of restoring bladder function in baboons, improving anatomical features with microgrooved scaffolds, and wirelessly detecting bladder contractions.
Deliverables
- Investigation of electrically conductive and non-conductive microgrooved POCO scaffolds for accelerated bladder tissue regeneration
- Investigation of wireless bioelectronic strategies to monitor real-time bladder dynamics
Technical requirements
- Mechanically compatible biodegradable elastomer scaffold (poly(1,8 octamethylene citrate-co-octanol) (POCO))
- Autologous bone marrow-derived mesenchymal stromal cells (MSCs)
- Hematopoietic stem/progenitor cells (CD34+ HSPCs)
- Microgrooved POCO scaffolds
- Biointegrated electronic strain gauge
- Stretchable electronics integrated into citrate-based elastomers
- Electrically conductive POCO scaffolds
