ALZHEIMER'S DISEASE SEQUENCING PROJECT PHENOTYPE HARMONIZATION CONSORTIUM - ABSTRACT IN RESPONSE TO PAR-20-099 “HARMONIZATION OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (AD/RD) GENETIC, EPIDEMIOLOGIC, AND CLINICAL DATA TO ENHANCE THERAPEUTIC TARGET DISCOVERY”, WE HAVE ASSEMBLED A MULTIDISCIPLINARY TEAM THAT INCLUDES EXPERTS IN NEUROIMAGING, NEUROPSYCHOLOGY, FLUID BIOMARKERS, NEUROPATHOLOGY, AND VASCULAR CONTRIBUTIONS TO ADRD TO WORK IN CLOSE PARTNERSHIP WITH THE NIH AND THE ALZHEIMER’S DISEASE SEQUENCING PROJECT (ADSP). OUR ADSP PHENOTYPE HARMONIZATION CONSORTIUM, OR “ADSP-PHC”, SEEKS TO WORK IN COORDINATION WITH EXISTING ADSP WORKGROUPS AND INITIATIVES TO (1) STREAMLINE ACCESS TO ENDOPHENOTYPE DATA, (2) PROVIDE HIGH QUALITY ENDOPHENOTYPE HARMONIZATION ACROSS MULTIPLE RESEARCH DOMAINS, AND (3) PROVIDE COMPREHENSIVE DOCUMENTATION OF BOTH DATA AVAILABILITY AND HARMONIZATION PROCEDURES. THIS PROJECT INCLUDES TWO COORDINATING CENTERS, THREE CORES, AND EIGHT DOMAIN- SPECIFIC HARMONIZATION

Summary

ALZHEIMER'S DISEASE SEQUENCING PROJECT PHENOTYPE HARMONIZATION CONSORTIUM - ABSTRACT IN RESPONSE TO PAR-20-099 “HARMONIZATION OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (AD/RD) GENETIC, EPIDEMIOLOGIC, AND CLINICAL DATA TO ENHANCE THERAPEUTIC TARGET DISCOVERY”, WE HAVE ASSEMBLED A MULTIDISCIPLINARY TEAM THAT INCLUDES EXPERTS IN NEUROIMAGING, NEUROPSYCHOLOGY, FLUID BIOMARKERS, NEUROPATHOLOGY, AND VASCULAR CONTRIBUTIONS TO ADRD TO WORK IN CLOSE PARTNERSHIP WITH THE NIH AND THE ALZHEIMER’S DISEASE SEQUENCING PROJECT (ADSP). OUR ADSP PHENOTYPE HARMONIZATION CONSORTIUM, OR “ADSP-PHC”, SEEKS TO WORK IN COORDINATION WITH EXISTING ADSP WORKGROUPS AND INITIATIVES TO (1) STREAMLINE ACCESS TO ENDOPHENOTYPE DATA, (2) PROVIDE HIGH QUALITY ENDOPHENOTYPE HARMONIZATION ACROSS MULTIPLE RESEARCH DOMAINS, AND (3) PROVIDE COMPREHENSIVE DOCUMENTATION OF BOTH DATA AVAILABILITY AND HARMONIZATION PROCEDURES. THIS PROJECT INCLUDES TWO COORDINATING CENTERS, THREE CORES, AND EIGHT DOMAIN- SPECIFIC HARMONIZATION