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Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)

US · MD National Institutes of Health (NIH) grant open #PAR-24-280
Response due Nov 02, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting R01 research grant applications for clinical observational (non-interventional) studies focused on musculoskeletal, rheumatic, and skin diseases. This is a Funding Opportunity Announcement (FOA) for investigator-initiated observational research; clinical trials are explicitly excluded. The opportunity is open from December 2024 through November 2026, allowing multiple submission cycles during that window.

What they want

Applicants must propose clinical observational (non-interventional) research studies targeting musculoskeletal, rheumatic, and/or skin diseases under the NIH R01 grant mechanism. Clinical trials are explicitly prohibited under this announcement (PAR-24-280). Research should advance understanding of disease mechanisms, natural history, risk factors, or outcomes in the specified disease domains through observational methodologies (e.g., cohort studies, case-control studies, cross-sectional studies, registry-based research). Multiple submission cycles are anticipated across the open period (December 9, 2024 – November 2, 2026).
Technical requirements
  • Clinical trials are explicitly NOT allowed — only observational (non-interventional) study designs are eligible
  • Must conform to NIH R01 grant mechanism requirements
  • Research must address musculoskeletal, rheumatic, or skin diseases

How they evaluate

Submission: Grants.gov federal grants portal electronic submission

Risks & flags

  • Broad, standing FOA with a multi-year open window (Dec 2024 – Nov 2026) — likely a program announcement with multiple receipt dates rather than a single competitive award, which limits direct comparison of this record to a traditional RFP

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Clinical Observational (CO) Studies in Mus…
Due Nov 02
Onboard ↗