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Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-185
Response due Jan 07, 2028 · 00:00 UTC

Summary

This NIH funding opportunity announcement (PAR-25-185) solicits R01 research grant applications focused on the screening and functional validation of genomic variants associated with human congenital anomalies. Clinical trials are explicitly excluded. The opportunity is issued by the National Institutes of Health (HHS) and is open for a multi-year window from October 2024 through January 2028, suggesting multiple receipt/review cycles. Applicants are expected to conduct genomic and functional biology research aimed at understanding the genetic underpinnings of birth defects and developmental disorders.

What they want

Solicitation of R01 research grant applications for: (1) screening of genomic variants linked to human congenital anomalies, and (2) functional validation studies to characterize the biological significance of identified variants. Clinical trials are not allowed under this announcement. The opportunity follows a Program Announcement with Special Receipt, Referral, and/or Review Considerations (PAR) mechanism, implying specific study section routing or special review considerations apply.
Technical requirements
  • Research must focus on screening and/or functional validation of genomic variants associated with human congenital anomalies
  • Clinical trials are not allowed under this announcement
  • Must conform to NIH R01 grant mechanism requirements
  • Special receipt, referral, and/or review considerations apply per PAR mechanism

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Multi-year open window (Oct 2024 – Jan 2028) with rolling receipt dates is standard for NIH PARs — not a red flag in isolation, but worth confirming specific receipt dates in the full FOA
  • No dollar values or award ranges disclosed in the synopsis — full funding opportunity announcement should be reviewed for budget caps
  • PAR mechanism implies specific study section assignment which could disadvantage applicants unfamiliar with the designated review group

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Screening and Functional Validation of Gen…
Due Jan 07
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