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National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-353
Response due Oct 25, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting applications for the National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program focused on the treatment of mental disorders. This is a cooperative research grant mechanism (U19) that supports multi-component, collaborative research projects aimed at discovering and developing new drugs or devices to treat mental health conditions. Clinical trials are optional under this announcement. The opportunity is open for a multi-year window from January 2025 through October 2027.

What they want

Applicants must form cooperative research groups to conduct drug and/or device discovery, development, and translational research targeting mental disorders. Research may span early-stage discovery through preclinical and potentially early clinical development. The U19 mechanism requires a multi-project structure with an administrative core. Clinical trial components are optional. Work must align with NIH/NIMH priorities for advancing therapeutics for mental health conditions.
Technical requirements
  • Multi-project (U19) cooperative group structure required
  • Administrative core required
  • Research must target drug and/or device discovery/development for mental disorders
  • Clinical trial component optional

How they evaluate

Submission: Grants.gov electronic submission (federal grants portal)

Risks & flags

  • No dollar value or award ceiling disclosed in the synopsis — budget expectations unclear
  • Multi-year open window (Jan 2025–Oct 2027) with rolling submissions may favor established NIH-networked institutions with prior NCDDG experience
  • U19 multi-project mechanism is complex and favors large academic medical centers with existing infrastructure

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

National Cooperative Drug/Device Discovery…
Due Oct 25
Onboard ↗