Summary
1 PROJECT SUMMARY 2 3 A significant shift in the safety assessment of environmental chemicals is ongoing. This shift includes a reduction, 4 or in some cases elimination, of traditional toxicity testing in animals with the implementation of new approach 5 methodologies (NAMs). Although these emerging NAMs provide an attractive means for identifying teratogens 6 and other developmental toxicants, the absence of a quantitative framework for relating in vitro effects to 7 equivalent in vivo human exposures limits their use for public health. In Phase I, we successfully demonstrated 8 the im
