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Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

US · N/A National Institutes of Health (NIH) grant open #PAR-25-449
Response due Jun 07, 2028 · 00:00 UTC

Summary

This NIH funding opportunity (PAR-25-449) solicits R61/R33 phased clinical trial research proposals investigating mind and body interventions designed to restore whole person health through emotional well-being mechanisms. The R61 phase typically supports early-stage milestone-driven feasibility work, while the R33 phase supports the larger, more definitive clinical trial. The opportunity is open from September 2025 through June 2028, suggesting multiple submission cycles. The focus is on integrative health research at the intersection of mind-body medicine, emotional well-being, and whole person health outcomes.

What they want

Applicants must design and conduct phased clinical trials (R61 feasibility/milestone phase followed by R33 efficacy/effectiveness phase) examining mind and body interventions — such as meditation, yoga, tai chi, or similar modalities — that restore whole person health by operating through emotional well-being mechanisms. Research must include a required clinical trial component as specified in the PAR. Proposals must define measurable milestones for the R61 phase that, if met, trigger transition to the R33 phase.
Technical requirements
  • Must include a clinical trial component (Clinical Trial Required designation)
  • R61 phase must include defined, measurable milestones for transition to R33
  • Research must investigate emotional well-being as a mechanistic pathway
  • Interventions must qualify as mind and body modalities

How they evaluate

Submission: Grants.gov federal grants portal (PAR-25-449)

Risks & flags

  • Extremely long open window (nearly 3 years) suggests multiple receipt dates — applicants should confirm specific submission deadlines within the full FOA
  • Narrow mechanistic focus on emotional well-being as the pathway may favor research groups already working in this specific intersection, potentially limiting competition

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Mind and Body Interventions to Restore Who…
Due Jun 07
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