Summary
Impaired nitric oxide synthase-dependent vasodilation is a common hallmark of infectious, inherited, and metabolic vascular diseases ranging from malaria to atherosclerosis. Efforts to restore nitric oxide (NO) signaling have been limited by an incomplete understanding of NO regulation in human arteries. We discovered that humans express both alpha and beta globin, which together form tetrameric hemoglobin that interacts directly with eNOS to regulate NO signaling in our arteries. This work was published as a major research article in the premier cardiovascular medicine journal, Circulation, a
