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Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-051
Response due Aug 18, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting applications under the Blueprint Neurotherapeutics Network (BPN) program to support small molecule drug discovery and development targeting disorders of the nervous system. The funding mechanism is a UG3/UH3 phased cooperative agreement, with clinical trials listed as optional. The program aims to advance novel small molecule therapeutics from early discovery through development stages for neurological and nervous system conditions. This is a federal grant opportunity posted on Grants.gov, open to eligible research institutions and organizations.

What they want

Applicants must propose research programs focused on small molecule drug discovery and development for disorders of the nervous system. The UG3 phase covers early-stage milestone-driven discovery activities, while the UH3 phase supports advanced development. Clinical trials are optional under this announcement. Work must align with the NIH Blueprint Neurotherapeutics Network framework and comply with all NIH grant requirements.
Technical requirements
  • Research must focus on small molecule drug discovery and/or development
  • Target area restricted to disorders of the nervous system
  • Phased UG3/UH3 cooperative agreement structure required
  • Clinical trial component is optional but must be addressed in application
  • Must comply with NIH Blueprint Neurotherapeutics Network program requirements

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Announcement number PAR-25-051 suggests a Program Announcement with Review (PAR), which may have a pre-defined review group and could limit competitive breadth
  • Multi-year open window (Sept 2024 – Aug 2026) with rolling submissions may favor established NIH-networked institutions with prior BPN experience

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Blueprint Neurotherapeutics Network (BPN):…
Due Aug 18
Onboard