Summary
Research into how RNA modifications (epitranscriptome) regulate protein synthesis, particularly noncanonical translation initiation via upstream Open Reading Frames (uORFs), and its impact on cell fate under normal and stress conditions.
Regulation of translation initiation by the epitranscriptome
US · IL
NIH RePORTER
grant
awarded
#nih-1R35GM159598-01
What they want
The research program will integrate RNA biochemistry, chemical biology, transcriptomics, and cell biology to understand how RNA modifications regulate uORF expression and the adaptability of eukaryotic cells to stress conditions. It will also investigate genetic and physical interactions between RNA-modifying enzymes and translation factors influencing noncanonical translation initiation, and implement synthetic biology strategies to modulate aberrant uORF expression in transcript-specific manners. The long-term goal is to pioneer conceptual leaps and technological innovations to comprehend and manipulate the epitranscriptome for human health.
