Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-211

Response due Jun 02, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting research grant applications under a Phased Innovation Award (R61/R33) mechanism to enhance mechanistic research on precision probiotic therapies. The R61 phase supports milestone-driven exploratory research, while the R33 phase supports expanded development contingent on meeting R61 milestones. Clinical trials are optional under this announcement. The opportunity is a Program Announcement with Review (PAR), number PAR-25-211, open for multiple submission cycles through June 2027.

What they want

Applicants must propose mechanistic research focused on precision probiotic therapies. The funding mechanism is the NIH R61/R33 Phased Innovation Award: the R61 phase is a milestone-driven exploratory/developmental stage, and the R33 phase provides an expansion stage contingent on successful completion of R61 milestones. Clinical trials are optional (not required). Applications must align with NIH programmatic priorities related to gut microbiome, probiotic mechanisms, and precision medicine approaches. Multiple submission dates are available within the open/close window (10/31/2024 – 06/02/2027).

Technical requirements

Research must be mechanistic in nature focused on precision probiotic therapies
Must follow R61/R33 Phased Innovation Award structure with milestone-driven R61 phase
R33 phase contingent on successful R61 milestone completion
Clinical trial component is optional but permissible

How they evaluate

Submission: Grants.gov electronic submission portal

Risks & flags

Extremely long open window (over 2 years) suggests rolling/recurring solicitation rather than a single competition — competitive dynamics may vary significantly by cycle
Minimal detail provided in source text; full eligibility, budget caps, and scoring criteria require review of the full FOA on NIH GRANTS website

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541711

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Enhancing Mechanistic Research on Precisio…

Due Jun 02

Onboard ↗