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Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)

US · MD · Bethesda National Institutes of Health / National Center for Complementary and Integrative Health (NCCIH) grant open #PAR-25-274
Response due Nov 17, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH), through the National Center for Complementary and Integrative Health (NCCIH), is soliciting applications for feasibility clinical trials focused on mind and body interventions aligned with NCCIH high-priority research topics. This is an R34 mechanism, which funds planning and feasibility studies that lay the groundwork for larger-scale clinical trials. Applicants must propose a clinical trial as a required component of the award. The opportunity is open from November 2024 through November 2026, allowing for multiple submission cycles.

What they want

Applicants must design and conduct feasibility-stage clinical trials investigating mind and body interventions (e.g., meditation, yoga, acupuncture, spinal manipulation, massage, or similar complementary health approaches) that address NCCIH high-priority research topics. The R34 mechanism supports pilot/feasibility work including: development and refinement of study protocols, recruitment and retention strategy testing, preliminary data collection, and preparation for future large-scale efficacy or effectiveness trials. A clinical trial is required; observational or non-interventional studies are not eligible under this announcement.
Technical requirements
  • Clinical trial must be a required component of the proposed research (not optional)
  • Study must address NCCIH high-priority research topics
  • Must use mind and body intervention(s) as the primary focus
  • R34 mechanism applies — feasibility/pilot stage only, not full efficacy trials

How they evaluate

Submission: Electronic submission via Grants.gov federal grants portal

Risks & flags

  • Ultra-specific focus on NCCIH high-priority topics without public enumeration in this notice may favor applicants with prior NCCIH relationships or insider knowledge of agency priorities
  • Multi-year open window (2024–2026) with rolling submissions — timing of submission may advantage groups already in dialogue with program officers

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Feasibility Clinical Trials of Mind and Bo…
Due Nov 17
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