Summary
Abstract Sulfur mustard, also known as mustard gas, is a threat in chemical warfare and terrorism. Although major advances have been made in understanding mustard-induced skin injury, effective countermeasures are lacking. Under an R34 grant, we have been investigating shared and unique mechanisms of mustard- and arsenical- induced skin injury with single cell tanscriptomics and fluorescence lifetime imaging microscopy. Using nitrogen mustard as a surrogate for sulfur mustard, we unexpectedly found that dermal fibroblasts are damaged early after mustard exposure and that CDK8, a kinase compone
