Summary
The establishment and maintenance of polarity is a fundamental feature of eukaryotic cells. Molecular motors within cells transport a variety of cargo including RNAs, proteins, vesicles, and organelles. The asymmetric distribution of these cargos by motor proteins is the underlying basis of cell polarity. The focus of this application is on the microtubule motor, cytoplasmic Dynein. Dynein is responsible for the transport of most cellular cargo towards the microtubule minus-end. In the absence of cargo, Dynein has limited activity. Fully activating this motor requires the multi-subunit Dynacti
