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Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional)

US National Institutes of Health (NIH) grant open #PAR-25-227
Response due Jan 07, 2028 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting R01 research grant applications to study the natural history of disorders that are screenable during the newborn period. This is a Program Announcement with Review (PAR), meaning NIH has a sustained interest in funding research in this area over a multi-year window. Clinical trials are optional under this funding opportunity. The opportunity is broadly aimed at advancing understanding of conditions identifiable through newborn screening programs.

What they want

Applicants are invited to submit R01 research grant applications investigating the natural history of disorders that can be identified through newborn screening in the newborn period. Clinical trials are optional. The program announcement (PAR-25-227) is a multi-year standing opportunity open from November 2024 through January 2028, reflecting NIH's sustained programmatic interest in this research domain. Specific study designs, target conditions, and methodologies are to be detailed by applicants in accordance with NIH R01 application requirements.
Technical requirements
  • Must follow NIH R01 grant application requirements
  • Clinical trials are optional but permissible under this announcement
  • Research must focus on natural history of disorders screenable in the newborn period

How they evaluate

  • NIH peer review criteria: Significance, Investigator(s), Innovation, Approach, Environment (standard R01 review criteria)
Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Extremely long open window (over 3 years) is consistent with NIH Program Announcements but could obscure rolling review cycles and informal priority areas not stated in the synopsis
  • Minimal detail provided in the synopsis — full funding opportunity announcement (FOA) text not included, limiting full scope assessment

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Natural History of Disorders Screenable in…
Due Jan 07
Onboard ↗