Summary
This project aims to elucidate "whole person" biopsychosocial mechanisms underlying inter-individual differences in movement-evoked pain and functional limitations in knee osteoarthritis (OA).
Leveraging inter-individual differences in walking pain and impairment to elucidate whole-person mechanisms of knee osteoarthritis
US · IL
NIH
grant
awarded
#nih-1R01AR086796-01
What they want
The project involves an observational study to understand why individuals with knee OA experience varying levels of pain and functional impairment during walking. It will include comprehensive data collection from a large sample of knee OA patients, encompassing knee joint MRI and detailed biomechanics assessments. The study will identify key biopsychosocial factors associated with increases in knee pain during walking (using the 6-minute walk test) and after exercises, as well as factors linked to reduced function. The research will also explore the relationship between pain and gait over time during physical activity, utilizing both parametric hypothesis testing and data-driven machine-learning methods.
Deliverables
- Identification of key factors underlying inter-individual differences in movement-evoked pain in knee OA
Technical requirements
- Concurrent ambulatory brain imaging
- Gait biomechanics during 6-minute walk test (6MWT)
- Knee joint MRI
- Detailed biomechanics assessments
- Parametric hypothesis testing
- Data-driven, machine-learning methods
