Summary
Project Summary/Abstract Dr. Mark Arcario is a cardiothoracic anesthesiologist whose long-term goal is to be an independent physician- scientist studying molecular mechanisms of allostery in ion channels. His research background is in computational biophysics of membrane proteins with a focus on the effects of lipids and lipophiles on membrane protein structure and function. He has a special interest in pentameric ligand-gated ion channels (pLGICs) and mechanisms of anesthetic action. Several endogenous lipids, including neurosteroids, phospholipids, and fatty acids, are strong allosteric modu
