Summary
Project summary. Inflammation underlies majority of human diseases including diabetes, atherosclerosis, and cancer. These diseases are responsible for majority of deaths and represent substantial global health burden. Macrophages and T-cells, subsets of immune cells, have emerged as key mediators of inflammation. The role of biochemical cues in shaping the transcriptional response of these cells have been investigated. However, accumulating evidence has shown that physical factors also tune their phenotype and effector functions. Recent two-dimensional studies have shown that mechanical confin
