Summary
Project Summary The dynamic microtubule cytoskeleton mediates intracellular organization, generates forces for dividing or migrating eukaryotic cells, and forms tracks for intracellular trafficking. The fundamental properties of microtubules, including polarized growth and “dynamic instability” stem directly from the activities of their building blocks, the αβ-tubulin heterodimers. Tubulins are among the most highly expressed proteins in eukaryotic cells. Despite advances in understanding special mechanisms regulating tubulin translation and folding, we lack understanding of how -tubulins ar
