Summary
This research project investigates the role of hydrogen sulfide (H2S) dysregulation in skeletal muscle metabolic dysfunction and exercise intolerance in patients with cardiometabolic heart failure with preserved ejection fraction (HFpEF).
Research Project 1 - Allerton
US · IL
NIH
grant
awarded
#nih-2P20GM135002-06A1
What they want
The project aims to determine how reductions in H2S synthesis and bioavailability impair skeletal muscle metabolism and exercise intolerance in cardiometabolic HFpEF. It will use novel H2S detection methods to investigate the impact of skeletal muscle 3-mercaptopyruvate sulfurtransferase (3-MST) and endothelial cell cystathionine-γ-lyase (CSE) on exercise intolerance during HFpEF progression. The research will also determine the role of H2S on skeletal muscle metabolism and mitochondrial function.
Deliverables
- Investigation of the impact of skeletal muscle 3-MST and endothelial cell CSE on exercise intolerance during cardiometabolic HFpEF progression
- Determination of the role of H2S on skeletal muscle metabolism and mitochondrial function during cardiometabolic HFpEF
- Understanding of how H2S contributes to skeletal muscle function and metabolism in HFpEF
Technical requirements
- Novel H2S detection methods
