HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Clinical Trial Center and Clinical Centers (U01 Clinical Trial Optional)

US · MD National Institutes of Health (NIH) grant open #RFA-HL-27-008

Response due Jul 09, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is funding the HeartShare 2.0 initiative, a research program focused on refining heart failure subtypes and identifying treatment targets to enable personalized clinical trials. Awards will be made under the U01 cooperative agreement mechanism, with clinical trials optional. The opportunity encompasses both a Clinical Trial Center and multiple Clinical Centers. The goal is to advance precision medicine approaches to heart failure through subtype characterization and targeted intervention research.

What they want

Applicants are invited to respond to RFA-HL-27-008 under the U01 (Cooperative Agreement, Clinical Trial Optional) mechanism. The program seeks to establish a network of a Clinical Trial Center and multiple Clinical Centers to: (1) refine heart failure subtypes using advanced phenotyping or other methodologies; (2) identify treatment targets suitable for personalized clinical trials; and (3) conduct or support clinical trials aligned with precision medicine goals for heart failure patients. The NIH National Heart, Lung, and Blood Institute (NHLBI) is the sponsoring institute given the agency code HHS-NIH11.

Technical requirements

U01 Cooperative Agreement mechanism
Clinical Trial Optional designation
Applicants must propose either a Clinical Trial Center or a Clinical Center role
Research must address refinement of heart failure subtypes and identification of treatment targets

How they evaluate

Submission: Grants.gov federal grants portal (RFA-HL-27-008)

Risks & flags

Scope is highly specialized (heart failure subtype research with personalized clinical trial design), which may limit eligible applicants to a small pool of academic medical centers with existing heart failure research infrastructure

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541711

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

HeartShare 2.0: Refining Heart Failure Sub…

Due Jul 09

Onboard ↗